Webthere are 1 drugs known to interact with benzonatate, along with 1 disease interaction. Of the total drug interactions, 1 is moderate. Webjun 4, 2020 · yes. Doctors may combine mucinex and benzonatate because they treat coughs in different ways. Mucinex is a brand name for guaifenesin, which is an expectorant. It thins mucus, making it easier to cough up. Benzonatate is an antitussive that. Webjul 1, 2024 · when taking benzonatate, it's important to be aware of potential drug interactions. This medication may interact with certain antibiotics, antifungal. Webbenzonatate…